The U.S.-Israeli war on Iran is rattling businesses worldwide, driving up energy prices, squeezing supplies of critical raw materials and raising questions about the reliability of trade routes critical to the flow of goods from food to car parts. Below are the main disruptions so far: TRAVEL CHAOS The war has led to tens of thousands of flight cancellations, reroutings and schedule changes worldwide, shutting much of the Middle East's airspace, including Qatar's, due to missile and drone threats.